本片原聲由 Rolfe Kent 作曲。
世上最可怕的事情，不是被悲傷擊垮，而是無法從悲傷中站起來……查理(亞當·桑德勒 Adam Sandler飾)是一個9•11的直接受害者，他的妻兒和愛狗都在這場災難中喪生。查理從此一蹶不振，嚴重的自閉抑郁。他已經習慣了每天踩著電動滑車，戴著大耳機在街頭行尸走肉般游蕩，心靈巨大的創傷讓他回歸不了正常的生活。
　　艾倫（唐·錢德爾 Don Cheadle 飾）則是一個表面看來非常幸福的男人，有成功的事業和美滿的家庭，然而他承受的生活壓力是常人無法理解的，他的內心在暗暗苦撐。
　　直到有一天，艾倫在街頭遇上了查理。得知這個老同學為何變得如此頹唐后，艾倫心里便下定決心也幫他一把，讓他從低谷中走出來。他們一起談心，游戲，慢慢的發現彼此的心靈都從窒息中蘇醒過來。
如果你喜歡Reign Over Me的專輯《電影原聲 - Reign Over Me(從心開始)》里的歌曲，可以把下面的歌曲連接發給你的朋友:
1.Learning What Has Happened to Charlie - Reign Over Me
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2.Alan's Parents - Reign Over Me
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3.Disturbed by Questions - Reign Over Me
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4.Can He Come Out? - Reign Over Me
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5.Coffee in Grand Central Station - Reign Over Me
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6.The Loss of a Father - Reign Over Me
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7.Remar's Scent - Reign Over Me
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8.Alan Recognises/Breakfast Alone With the Family - Reign Over Me
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9.The Desire to Help - Reign Over Me
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10.Taxi Stand-Off - Reign Over Me
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11.Evaluation - Reign Over Me
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12.There's Going to Be a Hearing/I Hated Kitchen Talk - Reign Over Me
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13.Playing Collossus - Reign Over Me
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14.So Broken - Reign Over Me
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15.New Life - Reign Over Me
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16.Alan Opens Up - Reign Over Me
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17.Pictures in Court - Reign Over Me
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18.Charlie's Theme - Reign Over Me
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19.Remar's Theme - Reign Over Me
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20.Alan and Charlie - Reign Over Me
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21.A Lonely Life - Reign Over Me
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